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Installazione di unità di conversione gratuito!
Installazione di unità di conversione gratuito!
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Installazione di unità di conversione gratuito!
- UV-induced formation of DNA damage in cells and their . . .
87 most frequent UV-induced damage Factors such as the cell type, the spectrum of the 88 incident light and the specificity of the formation of damage in skin are also discussed 89 Last, a short overview of link between DNA damage and mutagenesis is provided, 90 especially in the light of recent next generation sequencing data
- Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA . . .
DNA damage results in (i) misincorporation of bases during replication process, (ii) hydrolytic damage, which results in deamination of bases, depurination, and depyrimidination [36], (iii) oxidative damage, caused by direct interaction of ionizing radiations (IR) with the DNA molecules, as well as mediated by UV radiation-induced free radicals
- Chapter 9 UV-Induced DNA Damage Detection by ELISA Analysis
UV-Induced DNA Damage Detection by ELISA Analysis Takamitsu A Kato Abstract A cyclobutane pyrimidine dimer (CPD) is a type of DNA damage that occurs when adjacent pyrimidine bases in DNA, typically thymine or cytosine, form covalent bonds with each other due to exposure to ultraviolet (UV) radiation
- Proteomic discovery of DEK and NUMA1 as new players in UV . . .
Here, we used a click chemistry-based proteomic approach to identify DEK and NUMA1 as novel regulators of UV-induced DNA lesion repair
- Genome-Wide Dynamic Evaluation of the UV-Induced DNA Damage . . .
The DNA damage response (DDR) is a collection of complex and dynamic mechanisms that ensures detection and repair of DNA damage as well as coordination of repair with other cellular phys-iological processes such as cell cycle arrest and damage tolerance Ultraviolet radiation (UVR) is a ubiquitous environmental source of Volume 10 | September
- Dynamic maps of UV damage formation and repair for the human . . .
Formation and repair of UV-induced DNA damage in human cells are affected by cellular context To study factors influencing damage formation and repair genome-wide, we developed a highly sensi-tive single-nucleotide resolution damage mapping method [high-sensitivity damage sequencing (HS–Damage-seq)] Damage maps of both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4
- UV-exposure, endogenous DNA damage, and DNA replication . . .
We demon-strate that UV-induced base substitutions, insertions and deletions are prominent even in sun-shielded skin In addition, we detect accumulation of mutations due to spontaneous deamination of methylated cytosines as well as insertions and deletions characteristic of DNA replication errors in these cells
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